HHS Adult and Adolescent Opportunistic Infections Guidelines Updated

The following two sections of the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV have been updated:

Candidiasis (Mucocutaneous): The Panel updated the text, treatment, pregnancy considerations, references, and treatment table and made the following key changes:

• Added important new information on spontaneous abortion in pregnant women after any exposure to fluconazole (low—even single-dose—or high exposure)
• Added a brief discussion on the gentian violet topical application randomized clinical trial for oral candidiasis and updated the treatment table
• Added a statement indicating that azole resistance can be seen in vulvovaginal candidiasis caused by non-C. albicans species
• Added details for the use of boric acid in azole-refractory C. glabrata vaginitis in the treatment table

Herpes Simplex Virus: The Panel updated references throughout the section and improved the readability of the text. In addition, the Panel made the following key changes:

• Updated information about the seroprevalence of HSV-1 and HSV-2 in the United States
• Addressed HSV-1 as a cause of genital herpes
• Provided additional information about the interpretation of type-specific HSV serologic assays
• Updated information about prevention methods for HSV-2 infection
• Updated information about treatment of acyclovir-resistant HSV infection

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